Profile
Dr. Sam J Mathew is an Associate Professor with a strong academic background. He earned his PhD from the University of Cologne, Germany, in 2006. Following this, he conducted postdoctoral research at the University of Utah, USA. Since 2019, Dr. Mathew has served as an Associate Professor at RCB. With expertise in his field, Dr. Mathew contributes significantly to research and education. His scholarly pursuits focus on areas such as [insert specific research interests if available]. Through his dedication to academia and research, Dr. Mathew plays a pivotal role in advancing knowledge and mentoring the next generation of scientists.
Current Focus Areas
Our research focuses on understanding mammalian development, stem cell regeneration, and diseases like rhabdomyosarcoma. We investigate cellular processes, gene regulation, and signaling pathways involved. Our work elucidates mechanisms of skeletal muscle differentiation, myosin heavy chain functions, and regulatory factors like TLE4 in muscle stem cells.
Selected Publications
Kumar, P., Zehra, A., Saini, M., and Mathew, S. J. (2023). Zeb1 and Tle3 are trans-factors that differentially regulate the expression of myosin heavy chain-embryonic and skeletal muscle differentiation. FASEB Journal 37(8):e23074. doi: 10.1096/fj.202201698RR
Agarwal M, Bharadwaj A, Mathew S.L. (2022) TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation Journal of Cell Science, 135:4
Pradhan AK, G. Kandasamy, U. Chatterjee, A. Bharadwaj, S.J. Mathew, R.J. Dohmen, and Palanimurugan R. (2021) Ribosome-associated quality control mediates degradation of the premature translation termination product Orf1p of ODC antizyme mRNA. FEBS Letters 595: 2015-2033. doi: 10.1002/1873-3468.14147
Agarwal M, A. Sharma, P. Kumar, A. Kumar, A. Bharadwaj, M. Saini, G. Kardon, and S.J. Mathew. (2020) Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development. Development 147(7). pii: dev184507. doi: 10.1242/dev.184507.
Mathew SJ, Rembold M, Leptin M. (2011) A role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Molecular and Cellular Biology 24:4978.