Profile
We investigate signaling events that trigger changes in gene expression during aging. Our research is uncovering molecular mechanisms of dietary restriction. Specifically, we explore the interplay of kinases, transcription factors, and co-regulators downstream of the nutrient-sensing pathways that regulate longevity, metabolism, stress response, and pathogen resistance. Additionally, we examine how micronutrients influence life history traits, and how animals have evolved regulatory mechanisms to counteract them. We are also interested in investigating how organisms detect damage in somatic cells and regulate germline development and reproductive aging, focusing on the role of nutrient-sensing pathways. Furthermore, we are exploring phytochemicals to treat complications associated with metabolic disorders and aging.
Current Focus Areas
Studying inter-tissue cross talk that regulates aging in response to different vitamin B12 content of diet; Studying inter-tissue crosstalk that regulates reproductive decision and aging of germline;
Selected Publications
Sarkar GC, Rautela U, Goyala G, Datta S, Anand N, Singh A, Singh P, Chamoli M, Mukhopadhyay A (2022) A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage. Development 150 (17): dev201472. (DOI:10.1242/dev.201472)
Garg A, Alam M, Bai S, Dandawate M, Kumari N, Gupta S, Agrawal U, Nagarajan P, Reddy DS, Kulkarni MJ, and Mukhopadhyay A^ (2023) Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes. ACS Pharmacology and Translational Science 6(2): 253–269. [http://doi.org/10.1021/acsptsci.2c00082]
Nair T, Chakraborty R, Singh P, Rahman SS, Bhaskar AK, Sengupta S and Mukhopadhyay A (2021) Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span. Aging Cell 21(1):e13518. (https://doi.org/10.1111/acel.13518).
Chamoli M*, Goyala A*, Tabrez SS*, Siddiqui AA, Singh A, Antebi A, Lithgow GJ, Watts JL and Mukhopadhyay A^ (2020) Polyunsaturated fatty acids and p38 MAPK pathway link metabolic reprogramming to cytoprotective gene expression during Dietary Restriction. Nature Communications 11:4865 (https://doi.org/10.1038/s41467-020-18690-4)
Matai L*, Sarkar GC*, Chamoli M, Malik Y, Kumar SS, Rautela U, Jana NR, Chakraborty K#, Mukhopadhyay A#^ (2019) Dietary restriction improves proteostasis and increases life span through Endoplasmic Reticulum hormesis. Proceedings National Academy of Sciences USA 116 (35) 17383-17392. (https://doi.org/10.1073/pnas.1900055116)