Profile
Transcriptomic analysis to identify key molecular players involved during host response to NDV challenge in different breeds and tissues of Gallus gallus. Different breeds of Gallus gallus were known to be having differential resistance against Newcastle Disease Virus (NDV) infection. Differentially expressed genes which were thought to be involved in this pattern of resistance were already studied. Here we are analysing the transcriptomic data of various tissues of Gallus gallus for studying the lncRNAs involved in regulation of these genes. Functional annotation using co-expression analysis reveals the involvement of lncRNAs in the regulation of various pathways. Additionally, the role of lncRNAs as putative micro RNA precursors, and the interaction of deferentially expressed Genes with transcription factors and micro RNAs will be identified.
Current Focus Areas
Our group majorly focuses on Transcriptomics, Proteomics and Genomics, including application of data mining, application of bioinformatics tools, and structure-activity relationships.
Selected Publications
Vanamamalai VK, E P, T R K, Sharma S. 2023 Integrated analysis of genes and long non-coding RNAs in trachea transcriptome to decipher the host response during Newcastle disease challenge in different breeds of chicken. Int J Biol Macromol. 253 1-16 (127183)
Jali I, Vanamamalai VK, Garg P, Navarrete P, Gutiérrez-Adán A, Sharma S. 2022 Identification and differential expression of long non-coding RNAs and their association with XIST gene during early embryonic developmental stages of Bos taurus. Int J Biol Macromol. 229 896-908
Garg P, Vanamamalai VK, Jali I, Sharma S. 2022 In silico prediction of the animal susceptibility and virtual screening of natural compounds against SARS-CoV-2: Molecular dynamics simulation based analysis. Front Genet. 13 1-15
Vanamamalai VK, Garg P, Kolluri G, Gandham RK, Jali I, Sharma S. 2021 Transcriptomic analysis to infer key molecular players involved during host response to NDV challenge in Gallus gallus (Leghorn & Fayoumi). Sci Rep. 11 1-14
Kushwaha SK, Kesarwani V, Choudhury S, Gandhi S, Sharma S. 2020 SARS-CoV-2 transcriptome analysis and molecular cataloguing of immunodominant epitopes for multi-epitope based vaccine design. Genomics. 112 5044-5054