Profile
In his present capacity Dr. Bishnoi is leading a group of young researchers dedicated to metabolic disorders (obesity and type-2 diabetes) research with special focus on role of ion channel receptors, TRP channels and their modulation. His laboratory provides molecular evidence for development of solutions for obesity pandemic using different innovative approaches including of thermoregulation in brown adipose tissue, browning of white adipose tissue and balancing gut mucin layer homeostasis. Dr. Mahendra Bishnoi completed his PhD from University Institute of Pharmaceutical Sciences, Panjab University in Pharmacology. He had post-doctoral training at laboratories of Dr. Adrian Bruijnzeel (Nicotine Addiction research laboratory) at McKnight Brain Institute, University of Florida, Gainesville, Florida, USA and Dr. Louis S. Premkumar (Ion channels and disease research laboratory) Department of Pharmacology, Southern Illinois University- School of Medicine Springfield, Illinois, USA.
Current Focus Areas
a) Receptor, diet and nutrigenomics ( Studies on Transient Receptor Potential (TRP) channel mediated modulation and dietary constituents in “browning” of white adipose tissue to modulate obesity and related complications; TRP channels as nutritional sensor in gut and biomarkers for nutritional status)
b) Food, Gut and metabolic health (Neuronal and non-neuronal regulation of mucin secretion and its functional application in preventing disease).
Selected Publications
Sodhi RK, Kumar H, Singh R, Bansal Y, Singh Y, Kondepudi KK, Bishnoi M*, Kuhad A*. Allyl isothiocyanate, a TRPA1 agonist, protects against olanzapine-induced hypothalamic and hepatic metabolic aberrations in female mice. Biochemical Pharmacology, 2024, 222,116074.
Kaur J, Singh DP, Kumar V, Kaur S, Bhunia RK, Kondepudi KK, Kuhad A, Bishnoi M. Transient Receptor Potential (TRP) based polypharmacological combination stimulates energy expending phenotype to reverse HFD-induced obesity in mice. Life Sci. 2023 ;324: 121704. doi: 10.1016/j.lfs.2023.121704.
Kumar V, Kumar V, Mahajan N, Kaur J, Devi K, Dharavath RN, Singh RP, Kondepudi KK, Bishnoi M. Mucin secretory action of capsaicin prevents high fat diet-induced gut barrier dysfunction in C57BL/6 mice colon. Biomed Pharmacother. 2022, 145:112452. doi: 10.1016/j.biopha.2021.112452.
Khare P, Mangal P, Baboota RK, Jagtap S, Kumar V, Singh DP, Boparai RK, Sharma SS, Khardori R, Bhadada SK, Kondepudi KK, Chopra K, Bishnoi M. Involvement of Glucagon in Preventive Effect of Menthol Against High Fat Diet Induced Obesity in Mice. Front Pharmacol. 2018, 9:1244.
Bishnoi M, Khare P, Brown L, Panchal SK. (2018). Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy. Obes Rev. 2018, 19(9):1269-1292.