Profile
Dr Seth is trained as a neurovirologist and possess expertise in neuroinfections, stem cell biology and virus induced neurodegeneration. His research involves understanding how neurotropic viruses and their proteins affect brain functions. More precisely, Dr Seth's lab has taken up challenges of direct relevance to global health problems - particularly HIV-1, drug abuse, Zika virus mediated neuropathogenesis, and very recently effect of SARS-CoV2 on human brain in long COVID survivors. He is known for his pioneering work to understand the cellular and molecular mechanisms of glia mediated neuronal damage in viral infections in HIV-1 and Zika viruses. The National Academy of Sciences India, National Academy of Medical Sciences and Indian Academy of Neurosciences (IAN) have elected him their Fellow. He has been appointed as area expert to number of DBT, ICMR task forces to lend his expertise. He also serves on Editorial boards of numerous international journals in various capacities. Dr. Seth serves on the Board and Council of several international scientific bodies. He has multiple national and international collaborations.
Current Focus Areas
Understanding the cellular and molecular mechanisms of virus induced neurodegeneration with an aim to reduce the global burden of viral sequalae in survivors of neuroinfections.
Develop new 2D and 3D models to study disorders of human brain development using cells of human origin
Selected Publications
Bindu, Pandey, H. S. and Seth, P. (2023). Interplay between Zika virus-induced autophagy and neural stem cell fate determination. Molecular Neurobiology https://doi.org/10.1007/s12035-023-03704-1
Arora, H., Prajapati, B. and Seth, P. (2023) Potential role of lncRNA in impairing cellular properties of human neural progenitor cells following exposure to Zika virus E protein. Experimental Neurology 19. 114493. https://doi.org/10.1016/j.expneurol.2023.114493
Priyanka, Wadhwa, R., Chaudhuri, R. Nag, T.C, and Seth, P. (2020). Novel role of mortalin in attenuating HIV-1 Tat mediated astrogliosis. Journal of Neuroinflammation Volume 17(1), 276. doi: 10.1186/s12974-020-01912-3.
Fatima, M., Kumari, R., Schwamborn, J.C., Mahadevan, A., Shankar, S.K. Raja, R., and Seth, P. (2016) Tripartite Containing Motif 32 Modulates Proliferation of Human Neural Precursor Cells in HIV-1 Neurodegeneration. Cell Death and Differentiation 23(5):776-786. doi: 10.1038/cdd.2015.138
Mishra, M., Vitrevel, S., Sidappa, N.B., Ranga, U., and P. Seth. (2008). Clade Specific Neurotoxicity of HIV Tat in Human Neuron: Significance of Dicysteine C30C31. Motif. Annals of Neurology 63: 366-376.