Profile
Dr. Goel’s research delves into reproductive biotechnology, emphasizing stem cell biology, animal transgenesis, testis biology, spermatogenesis, and cryobiology. His journey began with evaluating the effects of growth factors and hormones on in vitro-produced sheep embryos. He then explored functional genomics by creating transgenic and gene knockout mouse models, unraveling various molecular mechanisms and signaling pathways. Notably, he achieved a milestone with the targeted deletion of the kappa-casein gene, resulting in lactation failure, marking the first gene-targeted mice in the country using embryonic stem (ES) cell technology. Dr. Goel's focus shifted to male germline stem cells as an alternative to ES cells for genetic modification in livestock such as pigs and buffaloes. Recently, his research has concentrated on cryopreservation, revival, and differentiation of germline stem cells to preserve the genetic potential of domestic and wild animals. His latest work identified the role of the testis-specific kinase PBK/TOPK in spermatogenesis using a gene knockout mice model. Dr. Goel aspires to develop mesenchymal stem cell cryo-banking for clinical applications in livestock and companion animals.
Current Focus Areas
Dr. Goel’s lab focuses on developing mesenchymal stem cell-based therapies to treat livestock diseases. His research aims to understand MSC biology, enhance their therapeutic potential through priming/conditioning, develop organoid culture systems for MSC therapy evaluation, and create stem cell-based products for livestock health.
Selected Publications
Abraham M, Kori I, Vishwakarma U and Goel S (2024). Comprehensive assessment of goat adipose tissue-derived mesenchymal stem cells cultured in different media. Scientific Reports, DOI: 10.1038/s41598-024-58465-1.
Dysregulation of angiogenesis-specific signalling in adult testis results in xenograft degeneration (2017), L Devi, L Pothana, S Goel*/Scientific reports/ 7 (1)/ 1-15 (*Corresponding author) (IF: 4.3), Cit: 10
Gonadal status of male recipient mice influences the germ cell development in immature buffalo testis tissue xenograft (2012). Reddy N, Mahla RS, Thati R, Suman SK, Jose J and Goel S*. Reproduction/ 135 (6)/ 785-796 (*Corresponding author) (IF: 3.9), Cit: 20
Expression of NANOG, but not POU5F1, points to the stem cell potential of primitive germ cells in neonatal pig testis (2008), Goel S, Fujihara M, Minami N, Yamada M, Imai H/Reproduction/135 (6)/785-796 (IF: 3.9), Cit: 71
Kappa-casein-deficient mice fail to lactate (2006), Shekar P C*, Goel S*, Rani S D, Sarathi D P, Alex J L, Singh S, Kumar S, Proceeding of the National Academy of Science of the USA/103 (21)/8000-8005/ (*Equally contributing first authors) (IF: 11.2), Cit: 62