Arockiasamy Arulandu

Group Leader, ICGEB

Profile

Education: Madurai Kamarai University, Madurai, India, MSc, 1993 Madurai Kamarai University, Madurai, India, PhD, 2000 Career History: Since 2016, Group Leader, Membrane Protein Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB) New Delhi, India 2006-2015, Staff Research Scientist, Structural and Computational Biology Group, ICGEB, New Delhi, India 2003-2006, Assistant Research Scientist, Texas A&M University, Texas, USA 2001-2003, Post-doctoral Research Associate, Texas A&M University 2000-2001, Post-doctoral Research Associate, University of Illinois at Chicago, USA 1994-2000, Junior and Senior Research Fellow (CSIR-NET), Madurai Kamaraj University, Tamil Nadu, India 1993-1994, Junior Research Fellow, Anna University, Chennai, Tamil Nadu, India.

Current Focus Areas

  • Structure-based drug discovery targeting lectin-like oxidized low-density lipoprotein (oxLDL) receptor LOX-1 for anti-atherosclerotic cardiovascular disease therapy

  • Structure-based drug discovery targeting Vitamin-C recycling Human chloride intracellular channels (HsCLICs) for anti-cancer therapy.

Selected Publications

  • Pothineni NVK, Karathanasis SK, Ding Z, Arulandu A, Varughese KI, Mehta JL. LOX-1 in Atherosclerosis and Myocardial Ischemia: Biology, Genetics, and Modulation. J Am Coll Cardiol. 2017;69(22):2759-2768. doi:10.1016/j.jacc.2017.04.010

  • Tomar A, Sahoo S, Aathi M, et al. Exploring the druggability of oxidized low-density lipoprotein (ox-LDL) receptor, LOX-1, a proatherogenic drug target involved in atherosclerosis. Biochem Biophys Res Commun. 2022;623:59-65. doi:10.1016/j.bbrc.2022.07.036

  • Khan MA, Mohammad I, Banerjee S, et al. Oxidized LDL receptors: a recent update [published online ahead of print, 2023 May 5]. Curr Opin Lipidol. 2023;10.1097/MOL.0000000000000884. doi:10.1097/MOL.0000000000000884

  • Sonkar KS, Achary VMM, Sahoo S, Reddy MK, Arockiasamy A. Biochemical and structural characterization of a robust and thermostable ascorbate recycling monodehydroascorbate reductase (MDHAR) from stress adapted pearl millet. Biochem Biophys Res Commun. 2023;662:135-141. doi:10.1016/j.bbrc.2023.04.034

  • Das BK, Khan WA, Sreekumar SN, et al. Plant dehydroascorbate reductase moonlights as membrane integrated ion channel. Arch Biochem Biophys. 2023;741:109603. doi:10.1016/j.abb.2023.109603

Skills & Proficiency

Drug Discovery Lead Design Lead optimization Assay Development Preclinical evaluation Atherosclerotic Cardiovascular Disease (ASCVD) oxLDL LOX-1 HsCLICs Cancer.
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