Profile
Dr Basu’s pre-doctoral studies were at School of Life Sciences, Viswa Bharati University, Santiniketan, doctoral work at Indian Institute of Chemical Biology, Kolkata and post-doctoral work at Pennsylvania State University College of Medicine, USA. Dr. Basu joined NBRC in June, 2004. Since then he has been working on understanding how neurotropic viruses cause abnormality in brain function and development. The major emphasis of his research is directed towards discovering therapeutic strategies against neuro-inflammatory and neuro-degenerative disorders. So far his work has not only highlighted the importance of neuro-immune response in regulating viral infection of the brain, but his work has been instrumental in filling the void needed to bridge the gap between translational and basic research centering infection of the brain.
Current Focus Areas
Among the latest endeavors of Dr. Basu’s lab are to study the potential role of gut microbiome in viral CNS infections via the gut-brain axis and to explore the network between the psyche, endocrine system, CNS pathology and immune response.
Selected Publications
I P S Venkatesh, A Majumdar, and A Basu (2024) Prophylactic administration of gut microbiome metabolites abrogated microglial activation and subsequent neuroinflammation in an experimental model of Japanese encephalitis. ACS Chemical Neuroscience 15(8):1712-1727
S Tripathi, S Sengar, B Shree, S Mohapatra, A Basu*, and Vivek Sharma (2023) An RBM10 and NF-κB interacting host lncRNA promotes JEV replication and neuronal cell death. Journ of Virology 97(12):e0118323 (*joint corresponding author)
S Chakraborty, and A Basu (2022) miR-451a Regulates Neuronal Apoptosis by Modulating 14-3-3ζ-JNK Axis upon Flaviviral Infection. mSphere 7(4): e0020822
M Bhaskar, S Mukherjee, and A Basu (2021) Involvement of RIG-I Pathway in Neurotropic Virus-Induced Acute Flaccid Paralysis and Subsequent Spinal Motor Neuron Death. mBio 12(6):e0271221
A Majumdar, I P S Venkatesh, V Swarup, and A Basu (2024) Short-chain fatty acids abrogate Japanese encephalitis virus-induced inflammation in microglial cells via miR-200a-3p/ZBTB20/IKβα axis. mBio (in press)