Dr Amit Kumar Pandey

Associate Professor, BRIC-THSTI

Profile

Dr. Amit Kumar Pandey obtained his B.V.Sc and A.H degree from Odisha Veterinary College, OUAT, Bhubaneswar, Odisha. He earned his M.V.Sc and PhD degrees from National Dairy Research Institute (NDRI), Karnal, Haryana and Indian Veterinary Research Institute (IVRI), Izatnagar, U.P., India respectively. Dr. Pandey pursued his postdoctoral training from University of Nebraska-Lincoln (UNL), Nebraska, USA and University of Massachusetts Medical School (UMASS), Worcester, Massachusetts, USA. After receiving the prestigious Ramalingaswami fellowship, from the Dept. of Biotechnology, he joined THSTI, as an Assistant Professor in 2011. He is currently working as Associate Professor, Centre of Tuberculosis Research, THSTI, Faridabad. His area of interest includes understanding mycobacterial pathogenesis with major focus on understanding various mechanisms of antibiotic and disease persistence leading to AMR in tuberculosis. He has published many research papers on tuberculosis biology and has over 24 years of experience in working with several in-vitro and in-vivo animal models of tuberculosis infection.

Current Focus Areas

  • Using genetic and multiomics approaches my group is trying to understand the fundamentals of the disease biology leading to (i) a better understanding of host-pathogen symbiosis, (ii) identification of novel drug targets (iii) shortening and potentiating the current anti-TB regimen by targeting persisters

Selected Publications

  • Pandey AK, Sassetti CM. Mycobacterial persistence requires the utilization of host cholesterol (2008). Proceedings of the National Academy of Sciences 105(11):4376-4380. doi:doi:10.1073/pnas.0711159105

  • Griffin JE, Pandey AK, Gilmore SA, et al. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations (2012). Chem Biol. Feb 24201219 (2):218-27. doi:10.1016/j.chembiol.2011.12.016

  • Talwar S, Pandey M, Sharma C, et al. Role of VapBC12 Toxin-Antitoxin Locus in Cholesterol-Induced Mycobacterial Persistence (2020). mSystems. 20205(6):10.1128/msystems. 00855-20.doi:10.1128/msystems.00855-20

  • Tyagi S, Sadhu S, Sharma T, et al. VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection (2024). Original Research. Frontiers in Immunology. 2024-March-07 202415doi:10.3389/fimmu.2024.1302163

  • Pal R, Talwar S, Pandey M, et al. Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis (2024). Tuberculosis 2024/03/01/2024145:102477. doi:https://doi.org/10.1016/j.tube.2024.102477

Skills & Proficiency

Tuberculosis Drug tolerance Antibiotic and disease persistence Anti-TB therapy AMR in Tuberculosis Vaccine BCG Immunology Mycobacterial Pathogenesis Host-Pathogen Interaction TB immunology Host-Directed Therapy Metabolic Plasticity Nutrient acquisition and utilization Mycobacterial Adaptation Mycobacterial Physiology and Metabolism Mycobacterial Lipids Mycobacterial Cell wall shortening anti-TB Regimen Potentiating Anti-TB Regimen
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