Profile
M. Sc. Utkal University, Bhubaneshwar, India Ph. D. Molecular Biophysics Unit, IISc, Bangalore, India Postdoctoral Research Dept. of Biochemistry, University of Alberta, Canada
Current Focus Areas
My laboratory aims at understanding the structural, functional and essentiality aspects of metabolic pathways using structural biology, biochemistry and in vivo studies and utilizes the outcome of these basic research studies for drug discovery for infectious diseases. We majorly focus on designing anti-TB molecules primarily through a target-based approach.
Selected Publications
• Ahmad M, Jha B, Bose S., Tiwari S., Dwivedy, A., Kar, D., Pal, R., Mariadasse, R., Parish, T., Jeyakanthan, J., Vinothkumar KR and Biswal BK (2023). Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis. IUCrJ, 10, 738-753.
• Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Bastos BL, Nair T, Riermeier A, Vayndorf EM, Judy Z. Wu JZ, Nilakhe A, Christina Q. Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schonfelder M, Iavarone F, Lorenzo GD, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmuller G, Kaeberlein M, Wackerhage H, Pal B, and Yadav VK (2023) Taurine deficiency as a driver of aging. Science 380, 1028 (2023) 9 June issue.
• Kumar D, Jha B, Bhatia I, Ashraf A, Dwivedy A and Biswal BK (2022) Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis Imidazoleglycerol-phosphate dehydratase. PROTEINS: Str. Func. Bio. info. 90:3-17.
• Dwivedy A, Ashraf A, Jha B, Kumar D, Agarwal N and Biswal BK (2021) De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation. Communications Biology 4, 410. https://doi.org/10.1038/s42003-021-01926-4.
• Jha B, Kumar D, Sharma A, Dwivedy A, Singh R and Biswal BK (2018) Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis. J. Biol. Chem. 293:10102-10118.