Profile
My laboratory is investigating RNA-based mechanisms of neuronal developmental disorder with particular emphasis on autism spectrum disorder. The laboratory has contributed in our understanding how RNA based mechanism could be leveraged to restore memory due to sleep loss and early life stress. Ongoing research programmes includes long non-coding RNA-mediated control of protein synthesis at the synapse and its impact on synapse development and memory deficits.
Current Focus Areas
long non-coding RNA-mediated control of developmental and behavioural deficits in autism
Selected Publications
Transcriptomics analysis identifies synapse-enriched lncRNAs required for excitatory synapse development and fear memory. Samaddar, S., Balakumar, S., Garg, K., Raj, N., Sultana, S., Mukherjee, U., Banerjee, D., Liau, W.S., Palakodeti, D., Bredy, T. W., and Banerjee, S. (2023). bioRxiv 2023.07.14.549055; doi: https://doi.org/10.1101/2023.07.14.549055; Under Revision
Gas5 regulates early-life-stress-induced anxiety and spatial memory. Banerjee, D., Sultana, S., and Banerjee, S., (2024). Journal Of Neurochemistry, in press. https://www.biorxiv.org/content/10.1101/2023.09.27.559778v1
Fear extinction is regulated by the activity of long non-coding RNAs at the synapse. Liau WS, Zhao Q, Bademosi A, Gormal RS, Gong H, Marshall PR, Periyakaruppiah A, Madugalle SU, Zajaczkowski EL, Leighton LJ, Ren H, Musgrove M, Davies J, Rauch S, He C, Dickinson BC, Li X, Wei W, Meunier FA, Fernández-Moya SM, Kiebler MA, Srinivasan B, Banerjee S, Clark M, Spitale RC, Bredy TW (2023). Nature Communications. 2023 Nov 22;14(1):7616. doi: 10.1038/s41467-023-43535-1
CRISPR based programmable RNA editing in primary neurons. Ravichandran, K., Khargonkar, T. Samaddar, S. and Banerjee, S. (2023) bioRxiv. doi: https://doi.org/10.1101/2023.03.10.532141; revised version communicated to Current Protocols2023 Sep;3(9):e886 doi: 10.1002/cpz1.886.
Homeostatic scaling is driven by a translation-dependent degradation axis that recruits miRISC remodeling. Balakumar, S*., Samaddar, S*., Mylavarapu, S.V.S., Clement, J.P. and Banerjee, S. (2021) PLOS Biology. doi: PLOS Biology 10.1371/journal.pbio.3001432.