Profile
I am trained in cancer biology and have over 17 years of experience. We are currently interested in understanding the cross talk between host immune system and disease especially in the contest tof gastrointestinal cancers and lupus
Current Focus Areas
The main focus of the laboratory is understanding the role of inflammation in physiology (innate immune response) and pathophysiology (cancer). We are particularly interested in the roles of Sphingosine 1-phosphate (S1P) in inflammation and carcinogenesis. We employ different pre-clinical , ex vivo and in vitro models in our study.
Selected Publications
Vijayan Y, James S, Viswanathan A, Aparna JS, Bindu A, Namitha NN, Anantharaman D, Lankadasari MB, Harikumar K B (2023). Targeting acid ceramidase enhances antitumor immune response in colorectal cancer.Journal of Advanced Research. Dec 21:S2090-1232(23)00403-4.
Mohammed S, Bindu A, Viswanathan A, Harikumar KB. (2023)Sphingosine 1-phosphate signaling during infection and immunity.Progress in Lipid Research 92:101251.
James S, Aparna JS, Babu A, Paul AM, Lankadasari MB, Athira SR, Kumar SS, Vijayan Y, Namitha NN, Mohammed S, Reshmi G, Harikumar K B. (2021).Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer .Biomolecules 11(5):661.
Mohammed S, Vineetha NS, James S, Aparna JS, Lankadasari MB, Maeda T, Ghosh A, Saha S, Li QZ, Spiegel S, Harikumar KB. (2020). Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity. The FASEB Journal 34:4329-4347.
Lankadasari MB, Aparna JS, Mohammed S, James S, Aoki K, Binu VS, Nair S, Harikumar KB (2018). Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine. Theranostics 13;8(14):3824-3840.