Profile
Dr. Ramchander works in the field of Human/Medical Genetics. He earned his Ph.D. from Osmania University in 2004 and has since dedicated his career to unravelling the genetic basis of inherited disorders, particularly within the Indian and Odisha populations. His lab employs diverse methods including linkage analysis, genetic association studies, and advanced sequencing to study complex hearing ailments and pediatric rare genetic disorders. Additionally, CRISPR/Cas9 based gene editing approaches are also being explored in zebrafish and mice models to investigate disease mechanisms and potential therapies. In the long term, his work at ILS is aimed at advancing genetic counselling, molecular diagnostics, and personalized therapeutics in India, aiming to improve healthcare outcomes through innovative genetic research.
Current Focus Areas
Molecular genetic studies of congenital hearing impairment
Genetic analysis of otosclerosis: mapping gene(s) and screening of candidate genes for mutations
Identification of genetic susceptibility to chronic or recurrent otitis media with effusion
Understanding the genetic basis and molecular mechanisms of paediatric rare genetic disorders
Selected Publications
Abhishek, K., Mohanta, B. K., Kumari, P., Dixit, A., & Ramchander, P. V. (2024). GeMemiOM: the curated database on genes, putative methylation study targets, and microRNA targets for otitis media. Journal of genetics and genomics, 51(2), 260–263.
Singh, N., Hansdah, K., Bouzid, A., Ray, C. S., Desai, A., Panda, K. C., Choudhury, J. C., Tekari, A., Masmoudi, S., & Ramchander, P. V. (2023). Genetic variants and altered expression of SERPINF1 confer disease susceptibility in patients with otosclerosis. Journal of human genetics, 68(9), 635–642.
Priyadarshi S, Hansdah K, Singh N, Bouzid A, Ray CS, Panda KC, Biswal NC, Desai A, Choudhury JC, Tekari A, Masmoudi S, Ramchander P. V. (2022) The risks of RELN polymorphisms and its expression in the development of otosclerosis. PLoS ONE 17(6): e0269558.
Manohar, S., Ramchander, P. V., Salvi, R., & Seigel, G. M. (2019). Synaptic Reorganization Response in the Cochlear Nucleus Following Intense Noise Exposure. Neuroscience, 399, 184–198.
Priyadarshi, S., Ray, C. S., Panda, K. C., Desai, A., Nayak, S. R., Biswal, N. C., & Ramchander, P. V. (2013). Genetic association and gene expression profiles of TGFB1 and the contribution of TGFB1 to otosclerosis susceptibility. Journal of bone and mineral research, 28(12), 2490–2497.