Profile
A systems biologist with a keen interest in metabolism and technology development. Training in Biotechnology and Chemical Engineering (from IISc Bangalore and Michigan State University), post-doc in Metabolism in NIH (US). Awarded Sigma-Xi award for excellence in graduate studies and Fellows Award for Research Excellence. Team leader in Systems Biology in ICGEB (2012 - 2017) and Group Leader since 2017. Published work with enzymes, bacteria, cyanobacteria, yeast, fungus, mammalian cells and rodents. Helped develop a fungal fermentation process to 15000 L scale. Focus on quantitative analysis of systems and processes, and maximizing rates, yield and titers. Published over 37 research articles in reputed peer-reviewed international journals and one patent application. Review Editor in Systems Microbiology in Frontiers Group of Journals and an Associate Editor in Springer Nature Applied Science. A member of the Technical Expert Committee on Energy, Environment and Forest Biotechnology, Department of Biotechnology.
Current Focus Areas
Our current focus is to improve rates, yields and titers of bioprocesses through application of systems biology, such as reconstruction and analysis of genome-scale metabolic models and metabolic flux analysis. We are also working actively on developing marine cyanobacteria for carbon capture and photosynthetic biomanufacturing
Selected Publications
1. Srivastava S, Kashiwaya Y, King MT, Baxa U, Tam J, Niu G, Chen, X, Clarke K, Veech RL. Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. FASEB J. 2012 Jun;26(6):2351-62. 2. 19. Ahmad A, Hartman H, Krishnakumar S, Fell DA, Poolman MG†, Srivastava S†. A Genome Scale Model of Geobacillus thermoglucosidasius (C56-YS93) reveals its biotechnological potential on rice straw hydrolysate. J. Biotechnol. 2017;251:30-37. 3. 12. Gupta JK, Rai P, Jain KK, Srivastava S. Overexpression of bicarbonate transporters in the marine cyanobacterium Synechococcus sp. PCC 7002 increases growth rate and glycogen accumulation. Biotechnol Biofuels. 2020, 13, 17. 4. 3. Upton DJ, Kaushal M, Whitehead C, Faas L, Gomez LD, McQueen-Mason SJ, Srivastava S, Wood AJ. Integration of Aspergillus niger transcriptomic profile with metabolic model identifies potential targets to optimise citric acid production from lignocellulosic hydrolysate. Biotechnol Biofuels 2022, 15:4. 5. 5. Ahmad M, Pathania R, Chowdhury A, Gupta JK, Srivastava S. Salt-stress adaptation of yeast as a simple method to improve high gravity fermentation in an industrial medium. Appl. Microbiol. Biotechnol. 2021. 105(20):8009-8018.