Profile
Nagendra Hegde obtained Bachelors in Veterinary Science, Masters in Veterinary Microbiology and Public Health, PhD in Veterinary Immunology, and post-doctoral training in virology and cell biology. He worked for a decade at Bharat Biotech Foundation, Hyderabad, before joining the National Institute of Animal Biotechnology, Hyderabad, in April 2017. His research experience spans veterinary and human virology, immunology and microbiology. His interests are to understand the epidemiology, genomics, and biology of viral and bacterial diseases, and to devise protective measures for these diseases. He has worked on bovine and major histocompatibility complex (MHC) and cell-mediated immunity (CMI), herpes virus immune evasion, adenovirus vectored vaccines, epidemiology molecular typing and genomics of bluetongue virus and bovine mastitis-associated staphylococci. He contributed to vaccine development at Bharat Biotech during his tenure there. He has recently embarked on One Health, working on anti-microbial resistance (AMR) and zoonotic diseases.
Current Focus Areas
Understanding bovine mastitis-associated staphylococci: species, antibiotic susceptibility, alternatives to antibiotics, biofilm formation, anti-biofilm compounds
Rhabdoviruses: reverse genetics, virus-cell interactions, vaccines, diagnostics, epidemiology, phytogeography, prevention and control, potential antivirals
Bluetongue: virus-cell interaction, tropism
Selected Publications
Kaur C, Asrith KP, Ramachandra SG, Hegde NR. (2024). Immunoinformatics-guided recombinant polypeptide-based enzyme-linked immunosorbent assay for seromonitoring of laboratory animals for minute virus of mice and Kilham rat virus. PLoS One. 2024 Feb 27;19(2):e0298742.
Prakash Rao VC, Ramakrishnaiah S, Isloor S, Doddamane R, Lakshman D, Maralavadi MSSR, Bhat A, Chandrashekar B, Natesan K, Kondabattula G, Hegde NR. (2023). Assessment of Immune Responses to Rabies Vaccination in Free-Ranging Dogs in Bengaluru, India. Vaccines (Basel). 2023 Apr 24;11(5):888.
Sivakumar R, Pranav PS, Annamanedi M, Chandrapriya S, Isloor S, Rajendhran J, Hegde NR. (2023). Genome sequencing and comparative genomic analysis of bovine mastitis-associated Staphylococcus aureus strains from India. BMC Genomics. 2023 Jan 25;24(1):44. doi: 10.1186/s12864-022-09090-7.
Pyasi S, Gupta A, Hegde NR, Nayak D. (2021). Complete genome sequencing and assessment of mutation-associated protein dynamics of the first Indian bovine ephemeral fever virus (BEFV) isolate. Vet Q. 2021 Dec;41(1):308-319.
Annamanedi M, Sheela P, Sundareshan S, Isloor S, Gupta P, Jasmeen P, Gargi M, Mallick S, Hegde NR. (2021). Molecular fingerprinting of bovine mastitis-associated Staphylococcus aureus isolates from India. Sci Rep. 2021 Jul 27;11(1):15228.