Profile
Prasenjit Guchhait, Ph.D, D.Sc, FNA, currently working as a Professor at RCB. Previously, I worked as an Assistant Professor at the Baylor College of Medicine, Houston, USA during 2008-2011.
Current Focus Areas
Investigating Signaling Pathways of Platelet-Leukocytes crosstalk leading to Thrombosis, Inflammation, and impaired Immune Responses in Human Diseases including polymorphism-associated disorders, hemolytic and autoimmune disorders, and Dengue/SARSCoV2 infections. Also, Identifying Biomarkers and Molecular Targets to Develop Potential Therapeutics.
1) SARS-CoV-2 infection: ARDS and pulmonary fibrosis and host immune response. 2) Dengue virus (DENV) and Japanese encephalitis virus (JEV) infection: pathogenesis and host immune response. 3) DENV: heterotypic infection and host immune response 4) Viral infections in diabetes: severity and host immune response
5) Diabetes: pathogenesis of inflammation, thrombosis and pulmonary fibrosis 6) Genetic polymorphism and high altitude adaptation in Tibetan highlanders 7) Diabetes in highlander population 8) Hemolytic disorders: pathogenesis of inflammation and thrombosis 9) Autoimmune disorders: pathogenesis of inflammation and thrombophilia
Selected Publications
1. Singh A, Ghosh R, Asuru TR, Prajapat S, Joshi G, Gaur KK, Shrimali NM, Ojha A, Vikram NK, Poncz M, Kalia M, Guchhait P* (2023) Inhibition of platelet factor 4:CXCR3 pathway prevents JEV and DENV infection. Journal of Thrombosis and Haemostasis, doi.org/10.1016/j.jtha.2023.11.015.
2. Shrimali NM, Agarwal S, Kaur S, Bhattacharya S, Bhattacharyya S, Prchal JT, Guchhait P* (2021) AKG inhibits thrombosis and inflammation by prolyl hydroxylase-2 mediated inactivation of phospho-Akt. EBioMedicine 73:103672.
3. Bhattacharya S, Shrimali NM, Mohammad G, Koul PA, Prchal JT and Guchhait P*. (2021) Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: a lesson in inflammatory response to inspired hypoxia. EBioMedicine 68:103418.
4. Ojha A, Bhasym A, Mukherjee S, Annarapu GK, Bhakuni T, Akbar I, Seth T, Vikram NK, Vrati S, Basu A, Bhattacharyya S, Guchhait P* (2019) Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses. EBioMedicine, 39: 332-347
5. Singhal R, Annarapu GK, Pandey A, Chawla S, Ojha A, Gupta A, Cruz MA, Seth T, Guchhait P* (2015) Hemoglobin interaction with GP1b-alpha induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis. Haematologica 100(12): 1526-33.