Profile
Dr. Sanjeev Das obtained B.Sc in Chemistry and M.Sc in Biochemistry from Calcutta University. He carried out doctoral studies at Indian Institute of Science. He did his post-doctoral training at Harvard Medical School before setting up his research group at National Institute of Immunology, New Delhi in 2008. His research broadly emphasizes on understanding the regulatory milieu of tumor suppressor proteins using proteomics based approaches. His lab has done seminal work on diverse tumor suppressors including p53, p73 and sirtuins. Dr. Das has published research articles in internationally acclaimed peer-reviewed journals such as Molecular Cell, PNAS and Nature Communications. He has received several awards for his contributions towards understanding of molecular mechanisms underlying tumorigenesis including the prestigious Shanti Swarup Bhatnagar Prize for Biological Sciences by the Council for Scientific and Industrial Research, Govt. of India.
Current Focus Areas
The focus of the laboratory is to understand the molecular mechanisms underlying the process of neoplastic transformation. The lab also has an active interest in understanding tumor cell metabolism. The lab employs diverse approaches including proteomics and metabolomics to examine the role of different regulatory networks in tumorigenesis.
Selected Publications
Ghosh M and Das S*. PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis (2021). Proc Natl Acad Sci USA, 118, e2105523118.
Kumari R, Deshmukh RS and Das S*. Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis (2019). Nature Communications, 10, 4255.
Bhardwaj A and Das S*. SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions (2016). Proc Natl Acad Sci USA, 113, E538-E547.
Sen N, Kumari R, Singh MI and Das S*. HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress (2013). Molecular Cell, 52, 406-420. (Featured Article)
Sen N, Satija YK and Das S*. PGC-1, a key modulator of p53, promotes cell survival upon metabolic stress (2011). Molecular Cell, 44, 621-634. (Featured Article)