Profile
Our ‘Micro & Nano Bio-Interface Lab’ focuses on micro- and nanoengineering for biology and medicine, particularly interested in a deeper understanding of the micro-environments or the micro-nano-bio interfaces between synthetic functional materials and biomolecules to develop high-throughput nanomedicine and biosensors for disease diagnostics and environment monitoring. We employ different techniques for our research activities, including microfluidics, bionanotechnology, bioanalytical chemistry, biofunctionalization, surface chemistry, and bioengineering. Furthermore, we integrate such understanding to develop hybrid microfluidic systems such as lab-on-chip (LoC) and microfluidic paper-based analytical devices (µ-PAD) with enhanced functionality, reduced cost, and improved sensitivity with the multiplexing assay.
Current Focus Areas
- Design of synthetic biofunctional nanomaterials, nucleic acid aptamers, and peptides and their applications in nano-biotechnology.
- Physicochemical and structural properties of such micro/nano bio-interfaces for biosensing, bioimaging, and biotherapy applications.
- Micro/nanofabrication techniques to create the next generation of biomaterials, medical devices, and point-of-care diagnostics.
Selected Publications
• Ngashangva, L. Ukita, Y. Takamura, Y. (2014). Development of programmable biosensor using solid phase peptide synthesis on microchip. Japanese Journal of Applied Physics, 53, 05FA09.
• Bhardwaj, R. Ngashangva, L. Ukita, Y. Takamura, Y. (2014). Development of oligopeptide-based novel biosensor by solid-phase peptide synthesis on microchip. Sensors and Actuators B: Chemical, 192, 818-825.
• Thungon, P. D.* Kakoti, A.* Ngashangva, L*. Goswami, P. (2017). Advances in developing rapid, reliable and portable detection systems for alcohol. Biosensors and Bioelectronics, 97, 83-99. (*equal 1st author contribution).
• Manoharan, S. Singh, N. K. Ngashangva, L. Goswami, P. (2020). A smartphone-based Fiber-optic aptasensor for label-free detection of Plasmodium falciparum glutamate dehydrogenase. Analytical Methods, 12, 1333-1341.
• Das, S. Ngashangva, L. Mog, H. Gogoi, S. Goswami, P. (2021). An insight into the mechanism of peroxidase-like activity of carbon dots. Optical Materials, 115, 111017.