Profile
The Gandhi group focused on the structural, magnetic, optical and transport properties of colloidal inorganic nanostructures, hybrid materials, thin films and lithographically patterned heterostructures. Our research occurs at the bio-nano-medical, magneto-electronic, and nano-energy interfaces for translational research. Dr Gandhi’s current research focus is broadly on two major, inter-related themes: 1. Bioengineering at the intersection of Novel Nanomaterials and Medicine focusing on diagnostics, imaging and therapy, with translational research and commercialization activities. Our group is focused on design of novel nanomaterials and encapsulation, and delivery of the nano-carriers to the desired site for efficient diagnostic, imaging, and therapy in livestock and poultry diseases. We synthesize different nanocomposites with various compositions, morphologies, with surface modifications that provide a category of powerful tools for efficient targeting and drug delivery. 2. Biosensor Development with emphasis on designing and fabrication of devices using modern lithography techniques. Our lab activities involved chemical modification of biomolecules, generation of polyclonal/monoclonal/recombinant antibodies. We develop Aptamer/DNA/Antibody based sensors using Novel Immunoassays, Lateral Flow dipstick assays, Electrochemical sensors, Microfluidic devices, Field Effect Transistors etc for detection of livestock and poultry diseases, environmental pollutants, hazardous chemicals.
Current Focus Areas
Our lab contributions to the translational research are indeed impressive. We have made significant strides in the development of diverse nanosensor technologies and immunoassays for clinical and environmental applications. Our labportfolio includes pioneering work in electrochemical, microfluidic, and paper-based nanosensors designed for rapid, point-of-care detection
Our lab is also involved in development of novel nanomaterials for targeted drug delivery and therapeutics, as well as we have designed of affordable and cost-effective detection on chip.
Selected Publications
Drishya Prakashan, Narlawar S. Shrikrishna, Manisha Byakodi, K. Nagamani, Sonu Gandhi$, Gold nanoparticle conjugate‐based lateral flow immunoassay (LFIA) for rapid detection of RBD antigen of SARS‐CoV‐2 in clinical samples using a smartphone‐based application. Journal of Medical Virology, 95 (2023), e28416.
Deepshikha Shahdeo, Akanksha Roberts, G J Archana, Subhasis Mahari, Narlawar Sagar Shrikrishna, K Nagamani, Sonu Gandhi$. Label free detection of SARS CoV-2 Receptor Binding Domain (RBD) Protein by Fabrication of Gold Nanorods deposited on Electrochemical Immunosensor (GDEI). Biosensors & Bioelectronics, 212 (2022), 114406.
Akanksha Roberts, Veerbhan Kesarwani, Rupal Gupta, Sonu Gandhi$. Electroactive Reduced Graphene Oxide for highly sensitive detection of secretory Non-Structural 1 protein: A potential diagnostic biomarker for Japanese Encephalitis Virus. Biosensors & Bioelectronics, 2022, 198, 113837.
Narlawar Sagar Shrikrishna, Sonu Gandhi$. Fabrication of graphene nanoplatelets embedded “partition cartridge” for efficient separation of target-bound ssDNA during SELEX. Materials Today Advances, 2021, 12, 100174.
Deepshikha Shahdeo, Veerbhan Kesarwani, Deepa Suhag, Jahangeer Ahmed, Saad M Alshehri, Sonu Gandhi$. Self-assembled chitosan polymer intercalating peptide functionalized gold nanoparticles as nanoprobe for efficient imaging of urokinase plasminogen activator receptor in cancer diagnostics. Carbohydrate Polymers, 2021, 266, 118138.