Profile
The Guha laboratory utilises genetic, cell biological and molecular approaches to discover the mechanisms that maintain airway homeostasis in the mammalian lung. Our research program is based on a variety of animal and cellular models in combination with environmental toxicant-based challenges.
Current Focus Areas
1. Regulation of stress responses in the airway epithelium focusing on cellular dsRNA and dsRNA-binding proteins 2. Regulation of cellular senescence in the airway epithelium in response to unmitigated genotoxic stress and damage 3. Regulation of post-injury repair of the airway epithelium focusing specifically on the smaller airways
Selected Publications
1. Guha A*, Deshpande A, Jain A, Sebastiani P, Cardoso WV*. Uroplakin 3a+ cells are a distinctive population of epithelial progenitors that contribute to airway maintenance and post-injury repair. Cell Reports Apr 11:19, 246-254 (2017). 2. Kizhedathu A, Chhajed P, Sain-Basu D, Lahari Y, Mukherjee T, Vinothkumar KR, Guha A*. Duox1-generated reactve oxygen species activate ATR(mei41)/Chk1(grapes)-dependent G2 arrest in tracheoblasts in Drosophila. eLife 10:e68636 (2021). 3. Sain Basu D, Bhavsar R, Gulami I, Lingamallu S, Muddashetty R, Veeranna C, Chattarji S, Thimmulappa R, Bhattacharya A, Guha A*. The Fragile X Mental Retarda-on Protein (FMRP) protects the lung from xenobiotic stress by facilitating the Integrated Stress Response. J Cell Sci 135 (9): jcs260033 (2022). 4. Lingamallu, S.M., Deshpande, A., Joy, N., Ganeshan, K., Lakas, D. and Guha, A*. 2023. Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that can repair airways following acute Notch inhibition. bioRxiv , pp.2023-11 (in advanced review)