Profile
My lab focuses on comprehending the molecular mechanisms underpinning neural development in both health and disease, utilizing mouse models and human iPSCs from individuals with mental disorders. Our goal is to cultivate a molecular and cellular understanding of neurobiological pathways implicated in neurodevelopmental and neuropsychiatric disorders, with the aim of advancing diagnostics and therapies for affected individuals.
Current Focus Areas
Chromatin regulation of cerebral cortex development in health and disease
Selected Publications
Phalnikar K, Srividya M, Mythri SV, Vasavi NS, Ganguly A, Kumar A, Padmaja S, Kalia K, Mishra SS, Dhanya SK, Paul P, Holla B, Ganesh S, Reddy PC, Sud R, Viswanath B*, Muralidharan B*. “Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder”, Oxford Open Neuroscience, 2024, kvae007, https://doi.org/10.1093/oons/kvae007, Article type: Research article
Channakkar A#, D’Souza L#, Kumar A, Kalia K, Prabhu S, Phalnikar K, Reddy PC, Muralidharan B*. “LSD1/KDM1A regulates neurogenesis in human neural stem cells through the repression of human-enriched extracellular matrix protein and cell adhesion genes” Stem Cells, 2023, sxad088, Article type: Research article
D’Souza L#, Chanakkar, A#, Muralidharan B*. “Chromatin remodelling complexes in cerebral cortex development and neurodevelopmental disorders” (2021), Neurochemistry International, 147, 105055, Article type: Review
Muralidharan B*. “Human in-vitro disease models to aid pathway and target discovery for neurological disorders” (2020) in Translational Biotechnology: A Journey from Laboratory to Clinics, Yasha Hasija (editor), Elsevier press, pp. 81-106, Article type: book chapter