PRECISION ON BIOTHERAPEUTICS
Precision biotherapeutics is a new era emerging in personalized medicine . biotherapeutics is a direct application of biotherapeutics derived from living organisms within the treatment of disease.such substance are endogenous or produced in laboratory. It is the new concept in the field of medicine that manages to change the treatment protocols aimed at patients with similar conditions to reach person’s broad biological profile and aims at precision medicine. This area combines genomic science and biotechnology and data science based treatments are aimed to more effective but with fewer adverse effect than conventional approach .With growing knowledge of dysregulation of disease ,we have also succeed in the design of therapies that target such disease at molecular level and create possibilities for previously unmanageable disease.
AIM:
The main aim of precision biotherapeutics is to develop treatment persuasion factors based on individual genetics , surroundings,and personal habits.Typical of conventional medicine where treatments are less or more homogenised and banners standard way, for instance precision biotherapeutics is applied in regards to unique biological characteristics of every patients.
In cancer patients,the treatment using precision biotherapeutics focusing on identifying genetic mutations driving a tumor’s growth
Rather than using indiscriminate cytotoxic approches such as chemotherapy ,which injuries not only the cancer tissues but also a normal cell.precision biotherapeutics aim to treat these mutations with the help of monoclonal antibodies ,small molecule inhibitors or other gene modifying tools such as CRISPR ( clustered regularly interspaced short palindromic repeats ). This precision involves unnecessary injury to normal structure and improve the chances of successfully treating the patients.
Genomics is one of the most important studies used in the precision biotherapeutics because decoding the human genome,which was accomplished in 2003 ,led to large scale genomic research that has found multiple genetic factors responsible for disease.
BACKGROUND :
Evolution of biotherapeutics: Trace the development of biotherapeutics from traditional biologics to current focus on precision medicine.the milestones like human genome project which provided the genetics insights necessary for personalized treatment.
Impact on genomic technologies : describe how advancements in genomic sequencing ,CRISPR,and other technologies have enabled the growth of precision biotherapeutics.
KEY COMPONENTS OF PRECISION BIOTHERAPEUTICS:
RNA Therapeutics: using RNA molecules to modulate gene expression or directly target diseases.
Protein engineering: designing and optimizing proteins for therapeutic applications.
Biological pathway modulation: Targeting specific biological pathways to treat diseases.
Cell and gene therapy: Using cells or gene to repair,replace,or regenerate damaged tissues.
Personalized medicine: Tailoring therapies to individual patients based on their unique profile .
Regulatory considerations: Ensuring compliance with regulatory frameworks to enable safe and effective therapies.
These components converge to create precise , effective, and personalized biotherapeutics ,revolotionizing disease treatment and patient care.
Precision biotherapeutics involves the design and application of therapeutic interventions that are precisely tailored to biological characteristics of individual patients . These therapies may include targeted drugs, gene therapy,cell based treatments each designed to interact with specific molecular targets or pathways associated with a disease. The foundation of this field lies in the genomics, proteomics and other omics technology that enable the detailed mapping patient ‘s unique genome of disease.

Akarsana S

University/College name : Dr N G P Arts and science college coimbatore