Over the last years, biomedicine has changed into a well-establish state which is mainly due to more sophisticated techniques in genomics and molecular biology, accompanied by advances acceleration of innovation from modern technology. Precision biotherapeutics is one of these developments, and it offers the opportunity to change paradigms for some cases like complicated conditions (cancer, autoimmune diseases or genetic disorders). Precision biotherapeutics aims to apply individualized treatments, customized for the specific biological and pathological characteristics of each patient, hence improving their efficacy while minimizing side effects.

Precision pharmacotherapy can be defined as a subclass of translational medicine that is dedicated to developing drugs (typically targeted small molecules or protein-based biologics), and gene therapy reagents intended for interaction with specific molecular targets within an individual patient’s body and tailored fractionation algorithms developed on de novo human ‘Pharmacogenomic-omics’ analyses. Its premise is diseases, especially chronic and life-threatening ones are not the same in all patients. Instead, they are more likely to result from the complex interplay of genetic, environmental and lifestyle factors. Ultimately, while two patients may be diagnosed with the same disorder a treatment that helped one patient does not mean it works on all those who share their diagnosis. Essential to biotherapeutical precision) is the ability to examine and understand specifically how a patient as well built like the disease at molecular or genetic levels. These can include genomic sequencing to detect mutations, profiling of proteins and metabolites, and even analyzing the patient’s immune response. By utilizing this detailed information, researchers and clinicians can design treatments that are specifically tailored to target the underlying mechanisms of the disease.

Brahmacharimayum Arisia Sharma

University/College name : Bhaskaracharya College of Applied Sciences, Delhi University